Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory

The Clinical Research, Investigation, and Systems Modeling of Acute Illness laboratory (CRISMA) is directed by Derek C. Angus MD, MPH, and co-directed by Gilles Clermont MD, MSc. This large team of clinicians, mathematicians, and epidemiologists enjoys superb funding from the NIH and multiple industrial sponsors. Regarded by many around the world as the leading investigative team carrying out studies of the clinical epidemiology of critical illness, Dr. Angus and his colleagues are actively studying the genetics of human sepsis, a syndrome that affects about 750,000 Americans every year and carries a mortality rate of almost 30 percent. Dr. Angus and his team of scientists have published papers in leading journals such as JAMA, Lancet, Critical Care Medicine, and the American Journal of Respiratory and Critical Care Medicine.
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